A Facile Synthesis of New 2-Amino-4H-pyran-3-carbonitriles by a One-Pot Reaction of -Bis(arylidene) Cycloalkanones and Malononitrile in the Presence of
Author(s) -
Zahed KarimiJaberi,
Baharak Pooladian
Publication year - 2012
Publication title -
the scientific world journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.453
H-Index - 93
eISSN - 2356-6140
pISSN - 1537-744X
DOI - 10.1100/2012/208796
Subject(s) - malononitrile , pyran , catalysis , environmentally friendly , chemistry , condensation reaction , condensation , reaction conditions , organic chemistry , ethanol , combinatorial chemistry , physics , ecology , thermodynamics , biology
A rapid and environmentally friendly method is developed for the synthesis of a series of new substituted 2-amino-4 H -pyran-3-carbonitriles through a one-pot condensation of malononitrile and α , α ′-bis(arylidene) cycloalkanones in ethanol by using K 2 CO 3 as a catalyst. Short experimental reaction times, excellent yields, no need to use cumbersome apparatus for purification of the products, and inexpensiveness and commercially availability of the catalyst are the advantages of this method.
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