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The aim of this study was to evaluate the antimicrobial activity of aqueous extract of  Psidium guineense  Swartz (Araçá-do-campo) and five antimicrobials (ampicillin, amoxicillin/clavulanic acid, cefoxitin, ciprofloxacin, and meropenem) against twelve strains of  Staphylococcus aureus  with a resistant phenotype previously determined by the disk diffusion method. Four  S. aureus  strains showed resistance to all antimicrobial agents tested and were selected for the study of the interaction between aqueous extract of  P. guineense  and antimicrobial agents, by the checkerboard method. The criteria used to evaluate the synergistic activity were defined by the fractional inhibitory concentration index (FICI). All  S. aureus  strains were susceptible to  P. guineense  as determined by the microdilution method. The combination of the  P. guineense  extract with the antimicrobial agents resulted in an eight-fold reduction in the MIC of these agents, which showed a FICI ranging from 0.125 to 0.5, suggesting a synergistic interaction against methicillin-resistant  Staphylococcus aureus  (MRSA) strains. The combination of the aqueous extract of  P. guineense  with cefoxitin showed the lowest FICI values. This study demonstrated that the aqueous extract of  P. guineense  combined with beta lactamics antimicrobials, fluoroquinolones, and carbapenems, acts synergistically by inhibiting MRSA strains.

the scientific world journal/thescientificworldjournal

In VitroSynergistic Effect ofPsidium guineense(Swartz) in Combination with Antimicrobial Agents against Methicillin-ResistantStaphylococcus aureusStrains