Open AccessHepatitis C virus-related internal ribosome entry sites are found in multiple genera of the family Picornaviridae
Author(s) -
Louisa S. Chard,
Marie-Eve Bordeleau,
Jerry Pelletier,
Junichi Tanaka,
Graham J. Belsham
Publication year - 2006
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/vir.0.81546-0
Subject(s) - picornaviridae , virology , biology , internal ribosome entry site , picornavirus , virus , ribosome , rna , genetics , enterovirus , gene
The internal ribosome entry site (IRES) elements from porcine enterovirus 8 and simian virus 2, two members of a proposed new genus within the family Picornaviridae, were characterized. These IRES elements, in common with the porcine teschovirus 1 IRES, were found to be related functionally and structurally to the IRES element from Hepatitis C virus, a member of the family Flaviviridae. Partial secondary structure predictions were derived and functional assays demonstrated that these IRES elements continued to be active when eIF4G was cleaved and when the activity of eIF4A was blocked.
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