Linkage map of protein–protein interactions of Porcine teschovirus | Zendy

Roland Zell | Zendy; Simone Seitz | Zendy; Andreas Henke | Zendy; Thomas Münder | Zendy; P Wutzler | Zendy

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Linkage map of protein–protein interactions of Porcine teschovirus

Author(s) -

Roland Zell,

Simone Seitz,

Andreas Henke,

Thomas Münder,

P Wutzler

Publication year - 2005

Publication title -

journal of general virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.55

H-Index - 167

eISSN - 1465-2099

pISSN - 0022-1317

DOI - 10.1099/vir.0.81144-0

Subject(s) - biology , two hybrid screening , protein–protein interaction , poliovirus , virology , genetics , microbiology and biotechnology , yeast , virus

A yeast two-hybrid study was conducted to catalogue the protein-protein interactions of the Porcine teschovirus non-structural proteins. Five homodimer, three reciprocal heterodimer and four unidirectional heterodimer interactions were observed. While several interactions are similar to those described in previous studies using enteroviruses, such as homo- and heterodimeric interactions of the 2B, 3CD and 3D proteins, several were not found previously. Among these is the binding of the leader protein L to the proteinases 3C and 3CD. Unlike the poliovirus 3C, the teschovirus 3C proteinase dimerizes and interacts with 2BC, 3CD and 3D. The strongest interactions were observed for L-3C, L-3CD and 3C-3CD.

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