Characterization of human papillomavirus type 120: a novel betapapillomavirus with tropism for multiple anatomical niches | Zendy

Danielle Bottalico | Zendy; Zigui Chen | Zendy; Boštjan J. Kocjan | Zendy; Katja Seme | Zendy; Mario Poljak | Zendy; Robert D. Burk | Zendy

Open Access

Characterization of human papillomavirus type 120: a novel betapapillomavirus with tropism for multiple anatomical niches

Author(s) -

Danielle Bottalico,

Zigui Chen,

Boštjan J. Kocjan,

Katja Seme,

Mario Poljak,

Robert D. Burk

Publication year - 2012

Publication title -

journal of general virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.55

H-Index - 167

eISSN - 1465-2099

pISSN - 0022-1317

DOI - 10.1099/vir.0.041897-0

Subject(s) - biology , tropism , virology , tissue tropism , clade , oral cavity , genome , human papillomavirus , papillomaviridae , phylogenetic tree , genetics , virus , gene , cancer , cervical cancer , medicine , orthodontics

Recent studies indicate that human papillomaviruses (HPVs) from the genera Betapapillomavirus and Gammapapillomavirus are abundant in the human oral cavity. We report the cloning and characterization of a 7304 bp HPV120 genome from the oral cavity that is related most closely to HPV23 (L1 ORF, 83.7 % similarity), clustering it in the genus Betapapillomavirus (β-PV). HPV120 contains five early and two late genes, but no E5 ORF. HPV120 was detected from heterogeneous human biological niches, including the oral cavity, eyebrow hairs, anal canal and penile, vulvar and perianal warts. Characterization of the clinical spectrum of HPV120 infections indicates a broader spectrum of epithelial tropism than appreciated previously for HPV types from the genus β-PV.

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