Open AccessA history estimate and evolutionary analysis of rabies virus variants in China
Author(s) -
Ming Peng,
Jie Yan,
Simon Rayner,
Shengli Meng,
Guozhang Xu,
Qin Tang,
Jie Wu,
Jie Luo,
Xiaoyan Yang
Publication year - 2009
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/vir.0.016436-0
Subject(s) - coalescent theory , biology , rabies virus , most recent common ancestor , virology , rabies , phylogenetic tree , china , confidence interval , virus , genetics , gene , evolutionary biology , statistics , geography , archaeology , mathematics
To investigate the evolutionary dynamics of rabies virus (RABV) in China, we collected and sequenced 55 isolates sampled from 14 Chinese provinces over the last 40 years and performed a coalescent-based analysis of the G gene. This revealed that the RABV currently circulating in China is composed of three main groups. Bayesian coalescent analysis estimated the date of the most recent common ancestor for the current RABV Chinese strains to be 1412 (with a 95 % confidence interval of 1006-1736). The estimated mean substitution rate for the G gene sequences (3.961x10(-4) substitutions per site per year) was in accordance with previous reports for RABV.
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