Open AccessProduction of protective gamma interferon by natural killer cells during early mouse hepatitis virus infection
Author(s) -
Gaëtan Thirion,
JeanPaul Coutelier
Publication year - 2009
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/vir.0.005876-0
Subject(s) - biology , virology , interferon , virus , interferon gamma , immune system , cytokine , hepatitis b virus , immunology
Gamma interferon (IFN-gamma) plays a major role in the protection against lethal infection with mouse hepatitis virus A59. IFN-gamma production reaches a maximum level 2 days after viral inoculation, especially in liver immune cells. Among these cells, natural killer cells are the major producers of this cytokine. Transfer experiments indicated that the protective role of IFN-gamma is mediated through a direct effect on cells targeted by the virus rather than through indirect activation of T lymphocytes.
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