Seroreactivity against Merkel cell polyomavirus and other polyomaviruses in chronic lymphocytic leukaemia, the MCC-Spain study | Zendy

Claudia Robles | Zendy; Delphine Casabonne | Zendy; Yolanda Benavente | Zendy; Laura Costas | Zendy; Eva GonzálezBarca | Zendy; Marta Aymerich | Zendy; Elı́as Campo | Zendy; Adonina Tardón | Zendy; José Juan JiménezMoleón | Zendy; Gemma CastañoVinyals | Zendy; Trinidad DierssenSotos | Zendy; Angelika Michel | Zendy; Lena M. Kranz | Zendy; Núria Aragonés | Zendy; Marina Pollán | Zendy; Manolis Kogevinas | Zendy; Michael Pawlita | Zendy; Sílvia de Sanjosé | Zendy

Open Access

Seroreactivity against Merkel cell polyomavirus and other polyomaviruses in chronic lymphocytic leukaemia, the MCC-Spain study

Author(s) -

Claudia Robles,

Delphine Casabonne,

Yolanda Benavente,

Laura Costas,

Eva GonzálezBarca,

Marta Aymerich,

Elı́as Campo,

Adonina Tardón,

José Juan JiménezMoleón,

Gemma CastañoVinyals,

Trinidad DierssenSotos,

Angelika Michel,

Lena M. Kranz,

Núria Aragonés,

Marina Pollán,

Manolis Kogevinas,

Michael Pawlita,

Sílvia de Sanjosé

Publication year - 2015

Publication title -

journal of general virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.55

H-Index - 167

eISSN - 1465-2099

pISSN - 0022-1317

DOI - 10.1099/vir.0.000167

Subject(s) - merkel cell polyomavirus , polyomavirus infections , virology , biology , serology , merkel cell carcinoma , immunology , chronic lymphocytic leukemia , jc virus , virus , antibody , bk virus , progressive multifocal leukoencephalopathy , leukemia , nephropathy , genetics , carcinoma , diabetes mellitus , endocrinology

Merkel cell polyomavirus (MCPyV) has been suspected to cause chronic lymphocytic leukaemia (CLL) but previous data are inconsistent. We measured seroreactivities of nine polyomaviruses (MCPyV, BKPyV, JCPyV, LPyV, KIPyV, WUPyV, HPyV-6, HPyV-7 and TSPyV) in 359 CLL cases and 370 controls using bead-based multiplex serology technology. We additionally tested two herpesviruses (HSV-1 and CMV). Associations between disease and viral seroreactivities were assessed using logistic regression. All human viruses showed high seroprevalences (69-99%) against structural proteins in controls but significantly lower viral seroprevalences in cases (58-94%; OR range = 0.21-0.70, P value < 0.05), except for MCPyV (OR = 0.79, 95% CI = 0.54-1.16). Lower seroreactivity levels were observed among CLL subjects, with significant differences already observed at early stages of disease, unrelated to treatment status. Seroreactivities against polyomavirus related oncoproteins were almost null. Our data suggest no association for MCPyV polyomavirus with CLL development and an unlikely association for other polyomaviruses tested.

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