Effects of α-phosphoglucomutase deficiency on cell wall properties and fitness in Streptococcus gordonii | Zendy

Alain Bizzini | Zendy; Paul Majcherczyk | Zendy; Siham. Beggah-Möller | Zendy; Blazenka Soldo | Zendy; José M. Entenza | Zendy; Muriel Gaillard | Zendy; Philippe Moreillon | Zendy; Vladimir Lazarević | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effects of α-phosphoglucomutase deficiency on cell wall properties and fitness in Streptococcus gordonii

Author(s) -

Alain Bizzini,

Paul Majcherczyk,

Siham. Beggah-Möller,

Blazenka Soldo,

José M. Entenza,

Muriel Gaillard,

Philippe Moreillon,

Vladimir Lazarević

Publication year - 2007

Publication title -

microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 179

eISSN - 1465-2080

pISSN - 1350-0872

DOI - 10.1099/mic.0.29256-0

Subject(s) - streptococcus gordonii , phosphoglucomutase , teichoic acid , biology , in vivo , mutant , virulence , in vitro , biochemistry , microbiology and biotechnology , strain (injury) , gene , bacteria , genetics , streptococcus , enzyme , peptidoglycan , anatomy

Streptococcus gordonii alpha-phosphoglucomutase, which converts glucose 6-phosphate to glucose 1-phosphate, is encoded by pgm. The pgm transcript is monocistronic and is initiated from a sigma(A)-like promoter. Mutants with a gene disruption in pgm exhibited an altered cell wall muropeptide pattern and a lower teichoic acid content, and had reduced fitness both in vitro and in vivo. In vitro, the reduced fitness included reduced growth, reduced viability in the stationary phase and increased autolytic activity. In vivo, the pgm-deficient strain had a lower virulence in a rat model of experimental endocarditis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research