Phospholipase A in Gram-negative bacteria and its role in pathogenesis | Zendy

Taghrid Istivan | Zendy; Peter J. Coloe | Zendy

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Phospholipase A in Gram-negative bacteria and its role in pathogenesis

Author(s) -

Taghrid Istivan,

Peter J. Coloe

Publication year - 2006

Publication title -

microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 179

eISSN - 1465-2080

pISSN - 1350-0872

DOI - 10.1099/mic.0.28609-0

Subject(s) - bacteria , microbiology and biotechnology , pathogenesis , virulence , phospholipase , biology , gram negative bacteria , virulence factor , bacterial outer membrane , protozoa , enzyme , bacterial cell structure , phospholipase a2 , biochemistry , immunology , escherichia coli , gene , genetics

Phospholipase A (PLA) is one of the few enzymes present in the outer membrane of Gram-negative bacteria, and is likely to be involved in the membrane disruption processes that occur during host cell invasion. Both secreted and membrane-bound phospholipase A(2) activities have been described in bacteria, fungi and protozoa. Recently there have been increasing reports on the involvement of PLA in bacterial invasion and pathogenesis. This review highlights the latest findings on PLA as a virulence factor in Gram-negative bacteria.

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