M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes | Zendy

Lisa I. Påhlman | Zendy; Erik Malmström | Zendy; Matthias Mörgelin | Zendy; Heiko Herwald | Zendy

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M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes

Author(s) -

Lisa I. Påhlman,

Erik Malmström,

Matthias Mörgelin,

Heiko Herwald

Publication year - 2007

Publication title -

microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.352

H-Index - 35

eISSN - 1465-2080

pISSN - 1350-0872

DOI - 10.1099/mic.0.2006/003285-0

Subject(s) - streptococcus pyogenes , tissue factor , coagulation , peripheral blood mononuclear cell , microbiology and biotechnology , monocyte , pathogen , disseminated intravascular coagulation , immunology , fibrin , biology , downregulation and upregulation , human blood , thromboplastin , human pathogen , medicine , pathology , bacteria , staphylococcus aureus , in vitro , biochemistry , physiology , gene , genetics

Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. Analysis of the resulting clots by transmission electron microscopy revealed that the cells were covered with a fibrin network that seemed to originate from the cell surface. Taken together, the results imply an important role for M proteins in the induction of haemostatic disorders in invasive streptococcal infectious diseases.

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