Trichoderma reesei RUT-C30 – thirty years of strain improvement | Zendy

Robyn Peterson | Zendy; Heleevalainen | Zendy

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Trichoderma reesei RUT-C30 – thirty years of strain improvement

Author(s) -

Robyn Peterson,

Heleevalainen

Publication year - 2011

Publication title -

microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 179

eISSN - 1465-2080

pISSN - 1350-0872

DOI - 10.1099/mic.0.054031-0

Subject(s) - trichoderma reesei , strain (injury) , cellulase , biology , mutagenesis , wild type , mutant , trichoderma , recombinant dna , microbiology and biotechnology , enzyme , food science , biochemistry , gene , anatomy

The hypersecreting mutant Trichoderma reesei RUT-C30 (ATCC 56765) is one of the most widely used strains of filamentous fungi for the production of cellulolytic enzymes and recombinant proteins, and for academic research. The strain was obtained after three rounds of random mutagenesis of the wild-type QM6a in a screening program focused on high cellulase production and catabolite derepression. Whereas RUT-C30 achieves outstanding levels of protein secretion and high cellulolytic activity in comparison to the wild-type QM6a, recombinant protein production has been less successful. Here, we bring together and discuss the results from biochemical-, microscopic-, genomic-, transcriptomic-, glycomic- and proteomic-based research on the RUT-C30 strain published over the last 30 years.

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