Identification and characterization of the Streptomyces globisporus 1912 regulatory gene lndYR that affects sporulation and antibiotic production | Zendy

Bohdan Ostash | Zendy; Yuriy Rebets | Zendy; Maksym Myronovskyy | Zendy; Olga Tsypik | Zendy; Iryna Ostash | Zendy; Oleksandr Kulachkovskyy | Zendy; Yuriy Datsyuk | Zendy; Tatsunosuke Nakamura | Zendy; Suzanne Walker | Zendy; Victor Fedorenko | Zendy

Open Access

Identification and characterization of the Streptomyces globisporus 1912 regulatory gene lndYR that affects sporulation and antibiotic production

Author(s) -

Bohdan Ostash,

Yuriy Rebets,

Maksym Myronovskyy,

Olga Tsypik,

Iryna Ostash,

Oleksandr Kulachkovskyy,

Yuriy Datsyuk,

Tatsunosuke Nakamura,

Suzanne Walker,

Victor Fedorenko

Publication year - 2011

Publication title -

microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 179

eISSN - 1465-2080

pISSN - 1350-0872

DOI - 10.1099/mic.0.045088-0

Subject(s) - actinorhodin , streptomyces coelicolor , biology , subfamily , streptomyces , gene , streptomycetaceae , regulator gene , genetics , transcription (linguistics) , actinomycetales , regulation of gene expression , bacteria , linguistics , philosophy

Here, we report the identification and functional characterization of the Streptomyces globisporus 1912 gene lndYR, which encodes a GntR-like regulator of the YtrA subfamily. Disruption of lndYR arrested sporulation and antibiotic production in S. globisporus. The results of in vivo and in vitro studies revealed that the ABC transporter genes lndW-lndW2 are targets of LndYR repressive action. In Streptomyces coelicolor M145, lndYR overexpression caused a significant increase in the amount of extracellular actinorhodin. We suggest that lndYR controls the transcription of transport system genes in response to an as-yet-unidentified signal. Features that distinguish lndYR-based regulation from other known regulators are discussed.

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