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Serratia marcescens, like several other Gram-negative bacteria, possesses two functional haem uptake systems. The first, referred to as the Hem system, can transport haem present at a concentration equal to or above 10(-6) M. It requires an active outer-membrane receptor which uses proton-motive force energy transmitted by the inner-membrane TonB protein. The other system, Has, takes up haem at lower concentrations and utilizes a small secreted haem-binding protein (haemophore) and its cognate TonB-dependent outer-membrane receptor HasR. Various combinations of mutations were used to examine haem uptake activity by the two systems in S. marcescens. The Hem uptake system enables S. marcescens to take up haem at a concentration of 10(-6) M in the presence of various levels of iron depletion. The Has system, which enables such uptake even in the presence of lower haem concentrations, requires higher iron depletion conditions for function. Has haem uptake requires the presence of HasB, a TonB paralogue encoded by the has operon. These two systems enable S. marcescens to take up haem under various conditions from different sources, reflecting its capacity to confront conditions encountered in natural biotopes.

The Hem and Has haem uptake systems in Serratia marcescens