Open AccessOrchestrating a heist: uptake and storage of metals by apicomplexan parasites
Author(s) -
Megan A. Sloan,
Dana Aghabi,
Clare R. Harding
Publication year - 2021
Publication title -
microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 179
eISSN - 1465-2080
pISSN - 1350-0872
DOI - 10.1099/mic.0.001114
Subject(s) - context (archaeology) , biology , apicomplexa , zinc , pathogen , metal , microbiology and biotechnology , chemistry , immunology , protozoal disease , malaria , paleontology , organic chemistry
The acquisition and storage of metals has been a preoccupation of life for millennia. Transition metals, in particular iron, copper and zinc, have vital roles within cells. However, metals also make dangerous cargos; inappropriate uptake or storage of transition metals leads to cell death. This paradox has led to cells developing elegant and frequently redundant mechanisms for fine-tuning local metal concentrations. In the context of infection, pathogens must overcome further hurdles, as hosts act to weaponize metal availability to prevent pathogen colonization and spread. Here, we detail the methods used by the Apicomplexa, a large family of eukaryotic parasites, to obtain and store essential metals.