Loving the poison: the methylcitrate cycle and bacterial pathogenesis | Zendy

Stephen K. Dolan | Zendy; Andre Wijaya | Zendy; Stephen M. Geddis | Zendy; David R. Spring | Zendy; Rafael SilvaRocha | Zendy; Martin Welch | Zendy

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Loving the poison: the methylcitrate cycle and bacterial pathogenesis

Author(s) -

Stephen K. Dolan,

Andre Wijaya,

Stephen M. Geddis,

David R. Spring,

Rafael SilvaRocha,

Martin Welch

Publication year - 2018

Publication title -

microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.352

H-Index - 35

eISSN - 1465-2080

pISSN - 1350-0872

DOI - 10.1099/mic.0.000604

Subject(s) - propionate , catabolism , catabolite repression , detoxification (alternative medicine) , bacteria , propionates , chemistry , mechanism (biology) , biology , biochemistry , microbiology and biotechnology , computational biology , metabolism , gene , medicine , mutant , genetics , alternative medicine , philosophy , epistemology , pathology , organic chemistry

Propionate is an abundant catabolite in nature and represents a rich potential source of carbon for the organisms that can utilize it. However, propionate and propionate-derived catabolites are also toxic to cells, so propionate catabolism can alternatively be viewed as a detoxification mechanism. In this review, we summarize recent progress made in understanding how prokaryotes catabolize propionic acid, how these pathways are regulated and how they might be exploited to develop novel antibacterial interventions.

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