Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe | Zendy

Stephen V. Gordon | Zendy; Tanya Parish | Zendy

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Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe

Author(s) -

Stephen V. Gordon,

Tanya Parish

Publication year - 2018

Publication title -

microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 179

eISSN - 1465-2080

pISSN - 1350-0872

DOI - 10.1099/mic.0.000601

Subject(s) - tuberculosis , mycobacterium tuberculosis , pathogen , human pathogen , microbiology and biotechnology , biology , antibiotics , drug resistance , virology , mycobacterium , immunology , bacteria , medicine , pathology , genetics

Mycobacterium tuberculosis is an expert and deadly pathogen, causing the disease tuberculosis (TB) in humans. It has several notable features: the ability to enter non-replicating states for long periods and cause latent infection; metabolic remodelling during chronic infection; a thick, waxy cell wall; slow growth rate in culture; and intrinsic drug resistance and antibiotic tolerance. As a pathogen, M. tuberculosis has a complex relationship with its host, is able to replicate inside macrophages, and expresses diverse immunomodulatory molecules. M. tuberculosis currently causes over 1.8 million deaths a year, making it the world's most deadly human pathogen.

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