Butanol is cytotoxic to Lactococcus lactis while ethanol and hexanol are cytostatic | Zendy

Anne-Mette Meisner Hviid | Zendy; Peter Ruhdal Jensen | Zendy; Mogens Kilstrup | Zendy

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Butanol is cytotoxic to Lactococcus lactis while ethanol and hexanol are cytostatic

Author(s) -

Anne-Mette Meisner Hviid,

Peter Ruhdal Jensen,

Mogens Kilstrup

Publication year - 2017

Publication title -

microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 179

eISSN - 1465-2080

pISSN - 1350-0872

DOI - 10.1099/mic.0.000441

Subject(s) - lactococcus lactis , lactic acid , bacteria , alcohol , butanol , ethanol , chemistry , alcohol tolerance , biochemistry , biology , microbiology and biotechnology , food science , genetics

Lactic acid bacteria currently used extensively by the dairy industry have a superior tolerance towards short-chain alcohols, which makes them interesting targets for use in future bio-refineries. The mechanism underlying the alcohol tolerance of lactic acid bacteria has so far received little attention. In the present study, the physiological alcohol stress response of Lactococcus lactis subsp. cremoris MG1363 towards the primary, even-chain alcohols ethanol, butanol and hexanol, was characterized. The alcohol tolerance of L. lactis was found to be comparable to those reported for highly alcohol-resistant lactic acid bacteria. Combined results from alcohol survival rate, live/dead staining, and a novel usage of the β-galactosidase assay, revealed that while high concentrations of ethanol and hexanol were cytostatic to L. lactis, high concentrations of butanol were cytotoxic, causing irreparable damages to the cell membrane.

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