Open AccessMultilocus variable-number tandem repeat analysis of Vibrio cholerae O1 El Tor strains harbouring classical toxin B
Author(s) -
Seon Young Choi,
Jehee Lee,
Yoon-Seong Jeon,
Hye Ri Lee,
Eunjin Kim,
M. Ansaruzzaman,
Nurul A. Bhuiyan,
Hubert P. Endtz,
S K Niyogi,
B L Sarkar,
G. Balakrish Nair,
Binh Minh Nguyen,
Nguyễn Trần Hiển,
Cécil Czerkinsky,
John D. Clemens,
Jongsik Chun,
Dong Wook Kim
Publication year - 2010
Publication title -
journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.017939-0
Subject(s) - vibrio cholerae , el tor , biology , microbiology and biotechnology , cholera toxin , cholera , variable number tandem repeat , tandem repeat , virology , genetics , bacteria , gene , genotype , genome
Atypical Vibrio cholerae O1 strains - hybrid strains (strains that cannot be classified either as El Tor or classical biotype) and altered strains (El Tor biotype strains that produce classical cholera toxin) - are currently prevalent in Asia and Africa. A total of 74 hybrid and altered strains that harboured classical cholera toxin were investigated by multilocus variable-number tandem repeat analysis (MLVA). The results showed that the hybrid/altered strains could be categorized into three groups and that they were distant from the El Tor strain responsible for the seventh cholera pandemic. Hybrid/altered strains with a tandem repeat of the classical CTX prophage on the small chromosome were divided into two MLVA groups (group I: Mozambique/Bangladesh group; group III: Vietnam group), and altered strains with the RS1-CTX prophage containing the El Tor type rstR and classical ctxB on the large chromosome were placed in two MLVA groups (group II: India/Bangladesh group; group III: India/Vietnam group).
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