Invasive paediatric Elizabethkingia meningoseptica infections are best treated with a combination of piperacillin/tazobactam and trimethoprim/sulfamethoxazole or fluoroquinolone | Zendy

J. Chan | Zendy; Chia Yin Chong | Zendy; Koh Cheng Thoon | Zendy; Nancy Wen Sim Tee | Zendy; Matthias Maiwald | Zendy; Joyce Ching Mei Lam | Zendy; Raja Bhattacharya | Zendy; Suresh Chandran | Zendy; Chee Fu Yung | Zendy; Natalie WH Tan | Zendy

Open Access

Invasive paediatric Elizabethkingia meningoseptica infections are best treated with a combination of piperacillin/tazobactam and trimethoprim/sulfamethoxazole or fluoroquinolone

Author(s) -

J. Chan,

Chia Yin Chong,

Koh Cheng Thoon,

Nancy Wen Sim Tee,

Matthias Maiwald,

Joyce Ching Mei Lam,

Raja Bhattacharya,

Suresh Chandran,

Chee Fu Yung,

Natalie WH Tan

Publication year - 2019

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.001021

Subject(s) - medicine , piperacillin/tazobactam , piperacillin , sulfamethoxazole , trimethoprim , tazobactam , meningitis , antimicrobial , mortality rate , retrospective cohort study , pediatrics , intensive care medicine , antibiotics , microbiology and biotechnology , pseudomonas aeruginosa , biology , genetics , bacteria

ObjectivesElizabethkingia meningosepticais a multi-drug-resistant organism that is associated with high mortality and morbidity in newborn and immunocompromised patients. This study aimed to identify the best antimicrobial therapy for treating this infection. Methods A retrospective descriptive study was conducted from 2010 to 2017 in a tertiary paediatric hospital in Singapore. Paediatric patients aged 0 to 18 years old with a positive culture forE. meningosepticafrom any sterile site were identified from the hospital laboratory database. The data collected included clinical characteristics, antimicrobial susceptibility and treatment, and clinical outcomes. Results Thirteen cases were identified in this study. Combination therapy with piperacillin/tazobactam and trimethoprim/sulfamethoxazole or a fluoroquinolone resulted in a cure rate of 81.8 %. The mortality rate was 15.4 % and neurological morbidity in patients with bacteraemia and meningitis remained high (75 %). Conclusions Treatment with combination therapy of piperacillin/tazobactam and trimethoprim/sulfamethoxazole or a fluroquinolone was effective in this study, with low mortality rates being observed.

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