Open AccessImprovement in serological diagnosis of pertussis by external quality assessment
Author(s) -
Kevin Markey,
Alex Douglas-Bardsley,
Cathy Asokanathan,
Norman K. Fry,
AlexMikael Barkoff,
Sabrina Bacci,
Csaba Ködmön,
Qiushui He
Publication year - 2019
Publication title -
journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000926
Subject(s) - external quality assessment , bordetella pertussis , whooping cough , medicine , serology , multiplex , harmonization , standardization , immunoassay , immunology , antibody , vaccination , biology , computer science , pathology , bioinformatics , bacteria , acoustics , physics , operating system , genetics
Serological analysis is an essential tool for the diagnosis of pertussis or whooping cough, disease surveillance and the evaluation of vaccine effectiveness against Bordetella pertussis. Accurate measurement of anti-pertussis toxin (anti-PT) IgG antibody levels in sera is essential. These measurements are usually performed using immunological methods such as ELISA and multiplex immunoassays. However, there are a large number of different assay systems available, and therefore standardization and harmonization between the methods are needed to obtain comparable data.
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