vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis | Zendy

Josefina Atrisco-Morales | Zendy; Verónica I. Martínez-Santos | Zendy; Adolfo Román-Román | Zendy; Judit Alarcón-Millán | Zendy; José De Sampedro-Reyes | Zendy; Iván Cruz-del Carmen | Zendy; Dinorah Nashely Martínez-Carrillo | Zendy; Gloria FernándezTilapa | Zendy

Open Access

vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis

Author(s) -

Josefina Atrisco-Morales,

Verónica I. Martínez-Santos,

Adolfo Román-Román,

Judit Alarcón-Millán,

José De Sampedro-Reyes,

Iván Cruz-del Carmen,

Dinorah Nashely Martínez-Carrillo,

Gloria FernándezTilapa

Publication year - 2018

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000660

Subject(s) - caga , helicobacter pylori , genotype , gastritis , chronic gastritis , virulence , microbiology and biotechnology , biology , allele , gene , genetics

Virulent genotypes of Helicobacter pylori vacA s1m1/cagA + /babA2 + have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is allele-dependent. The aims of this work were: (i) to determine the prevalence of H. pylori by type of chronic gastritis; (ii) to describe the frequency of cagA, babA2 and vacA genotypes in strains from patients with different types of chronic gastritis; (iii) to characterize the variable region of cagA alleles.

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