A hemin auxotrophic Enterobacter cloacae clinical isolate with increased resistance to carbapenems and aminoglycosides | Zendy

Tatsuya Tada | Zendy; Kohei Uechi | Zendy; Isamu Nakasone | Zendy; Zenji Miyazato | Zendy; Takashi Shinzato | Zendy; Kayo Shimada | Zendy; Mitsuhiro Tsuchiya | Zendy; Teruo Kirikae | Zendy; Jiro Fujita | Zendy

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A hemin auxotrophic Enterobacter cloacae clinical isolate with increased resistance to carbapenems and aminoglycosides

Author(s) -

Tatsuya Tada,

Kohei Uechi,

Isamu Nakasone,

Zenji Miyazato,

Takashi Shinzato,

Kayo Shimada,

Mitsuhiro Tsuchiya,

Teruo Kirikae,

Jiro Fujita

Publication year - 2017

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000655

Subject(s) - enterobacter cloacae , aztreonam , microbiology and biotechnology , hemin , biology , auxotrophy , enterobacter , enterobacteriaceae , cephalosporin , antibiotics , antibiotic resistance , escherichia coli , genetics , gene , imipenem , biochemistry , enzyme , heme

Small-colony variants (SCVs) were obtained from an Enterobacter cloacae clinical isolate in Okinawa, Japan. One variant showed auxotrophy for hemin with a deletion of 20 365 nucleotides, dosC-ydiK-mmuP-mmuM-tauA-tauB-tauC-tauD-hemB-yaiT-yaiV-ampH-yddQ-sbmA-yaiW-yaiY-yaiZ, including hemB, and was more resistant to aminoglycosides and carbapenems, but more susceptible to aztreonam, than the parent strain.

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