Virulence genes in isolates of Klebsiella pneumoniae from the UK during 2016, including among carbapenemase gene-positive hypervirulent K1-ST23 and ‘non-hypervirulent’ types ST147, ST15 and ST383 | Zendy

Jane F. Turton | Zendy; Zoë Payne | Zendy; Amy Coward | Zendy; Katie L. Hopkins | Zendy; Jack A. Turton | Zendy; Michel Doumith | Zendy; Neil Woodford | Zendy

Open Access

Virulence genes in isolates of Klebsiella pneumoniae from the UK during 2016, including among carbapenemase gene-positive hypervirulent K1-ST23 and ‘non-hypervirulent’ types ST147, ST15 and ST383

Author(s) -

Jane F. Turton,

Zoë Payne,

Amy Coward,

Katie L. Hopkins,

Jack A. Turton,

Michel Doumith,

Neil Woodford

Publication year - 2017

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000653

Subject(s) - virulence , biology , aerobactin , gene , microbiology and biotechnology , klebsiella pneumoniae , plasmid , pathogenicity island , genome , genetics , multilocus sequence typing , whole genome sequencing , virology , escherichia coli , genotype , enterobacteriaceae

Klebsiella pneumoniae is a concern because of its multidrug resistance and the ability of hypervirulent types, especially capsular type K1-clonal complex 23 (K1-CC23), to cause community-acquired, life-threatening infections. Hypervirulent types carry an array of virulence genes including rmpA/rmpA2, coding for capsule up-regulation. We sought to identify isolates carrying these elements among submissions to the UK national reference laboratory during 2016.

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