Mycobacterium tuberculosis hypoxic response protein 1 (Hrp1) augments the pro-inflammatory response and enhances the survival of Mycobacterium smegmatis in murine macrophages | Zendy

Changfeng Sun | Zendy; Guoping Yang | Zendy; Jinning Yuan | Zendy; Xuan Peng | Zendy; Chunxi Zhang | Zendy; Xiaoqian Zhai | Zendy; Tāo Luò | Zendy; Lang Bao | Zendy

Open Access

Mycobacterium tuberculosis hypoxic response protein 1 (Hrp1) augments the pro-inflammatory response and enhances the survival of Mycobacterium smegmatis in murine macrophages

Author(s) -

Changfeng Sun,

Guoping Yang,

Jinning Yuan,

Xuan Peng,

Chunxi Zhang,

Xiaoqian Zhai,

Tāo Luò,

Lang Bao

Publication year - 2017

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000511

Subject(s) - mycobacterium smegmatis , mycobacterium tuberculosis , microbiology and biotechnology , biology , tumor necrosis factor alpha , in vivo , immune system , nitric oxide , immunology , tuberculosis , medicine , pathology , endocrinology

The DosR/DosS two-component regulatory system of Mycobacterium tuberculosis regulates the expression of numerous genes under stress conditions and is important for the long-term survival of M. tuberculosis in the host. The rv2626c gene of M. tuberculosis is one of the most strongly induced transcripts of the dormancy regulon. This study focused on the immunological effects and possible function of Rv2626c in maintaining mycobacterial survival under various stress conditions.

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