Novel anti-staphylococcal and anti-biofilm properties of two anti-malarial compounds: MMV665953 {1-(3-chloro-4-fluorophenyl)-3-(3,4-dichlorophenyl)urea} and MMV665807 {5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide} | Zendy

Marta Zapotoczna | Zendy; Nabila Boksmati | Zendy; Sinead Donohue | Zendy; Baizurina Bahtiar | Zendy; Ahmad Boland | Zendy; Hamzah Al Somali | Zendy; Alysia Cox | Zendy; H. Humphreys | Zendy; James P. O’Gara | Zendy; Marian Brennan | Zendy; E. O’Neill | Zendy

Open Access

Novel anti-staphylococcal and anti-biofilm properties of two anti-malarial compounds: MMV665953 {1-(3-chloro-4-fluorophenyl)-3-(3,4-dichlorophenyl)urea} and MMV665807 {5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide}

Author(s) -

Marta Zapotoczna,

Nabila Boksmati,

Sinead Donohue,

Baizurina Bahtiar,

Ahmad Boland,

Hamzah Al Somali,

Alysia Cox,

H. Humphreys,

James P. O’Gara,

Marian Brennan,

E. O’Neill

Publication year - 2017

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000446

Subject(s) - resazurin , biofilm , staphylococcus aureus , cytotoxicity , microbiology and biotechnology , chemistry , antibiotics , bacteria , biology , in vitro , biochemistry , genetics

The treatment of device-related infections is challenging and current anti-microbial compounds have poor anti-biofilm activity. We aimed to identify and characterize novel compounds effective in the eradication of Staphylococcus aureus biofilms.

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