Accuracy of in vitro susceptibility tests for carbapenemase-producing Gram-negative bacteria | Zendy

Jingyong Sun | Zendy; Yingchun Xu | Zendy; Yunsong Yu | Zendy; Yuxing Ni | Zendy

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Accuracy of in vitro susceptibility tests for carbapenemase-producing Gram-negative bacteria

Author(s) -

Jingyong Sun,

Yingchun Xu,

Yunsong Yu,

Yuxing Ni

Publication year - 2015

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000067

Subject(s) - microbiology and biotechnology , gram negative bacteria , gram , bacteria , biology , in vitro , gram positive bacteria , antibiotics , escherichia coli , genetics , gene

Accurate susceptibility results on antibiotic-resistant bacteria are essential for proper treatment of infections. In this study, 100 metallo-β-lactamase (MBL)-producing strains and 95 isolates with Klebsiella pneumoniae carbapenemase (KPC) were tested for carbapenem susceptibility using two automated platforms, the Phoenix and Vitek-2 systems, and a manual Etest. Phoenix showed higher categorical agreements (97% for imipenem and 94% for meropenem) compared with those from Vitek-2 (92 and 74%) and Etest (89 and 96%), respectively, when testing MBL strains. Categorical agreement for imipenem tests with KPC-producing strains was 88.4% with the Phoenix system, 83.2% with the Vitek 2 system and 90.5% with the Etest. Categorical agreement was 100% for all tests with ertapenem. In conclusion, the Phoenix system demonstrated a higher accuracy than Vitek-2 in testing carbapenemase-producing strains, particularly in MBL strains.

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