False positive influenza A and B detections in clinical samples due to contamination with live attenuated influenza vaccine | Zendy

Susan E. Bennett | Zendy; Alasdair Maclean | Zendy; Arlene Reynolds | Zendy; Beatrix von Wissmann | Zendy; Rory Gunson | Zendy

Open Access

False positive influenza A and B detections in clinical samples due to contamination with live attenuated influenza vaccine

Author(s) -

Susan E. Bennett,

Alasdair Maclean,

Arlene Reynolds,

Beatrix von Wissmann,

Rory Gunson

Publication year - 2015

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000035

Subject(s) - clinical microbiology , microbiology and biotechnology , influenza vaccine , virology , medicine , biology , immunology , vaccination

Curran et al. (2012) described the detection of inactivated influenza A vaccine (IAV) contamination in clinical samples being sent for respiratory virus PCR testing. The authors concluded that the administration of IAV and clinical sampling in the same room resulted in vaccine strains contaminating surveillance swabs collected from patients with influenza-like illness (ILI)/respiratory illness. Herein we describe our recent similar experience in Scotland where we detected the recently licensed live attenuated influenza vaccine (LAIV) in clinical samples taken from patients with ILI.

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