Open AccessHPV-11 variability, persistence and progression to genital warts in men: the HIM study
Author(s) -
Ema Flores-Díaz,
Karen A. Sereday,
Silvaneide Ferreira,
Bradley Sirak,
João Simão Sobrinho,
Maria Luiza Baggio,
Lenice Galan,
Roberto C. Silva,
Eduardo LazcanoPonce,
Anna R. Giuliano,
Luisa L. Villa,
Laura Sichero
Publication year - 2017
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/jgv.0.000896
Subject(s) - sex organ , genital warts , hpv infection , biology , persistence (discontinuity) , etiology , virology , medicine , genetics , cervical cancer , human immunodeficiency virus (hiv) , cancer , geotechnical engineering , syphilis , engineering
HPV-11 and HPV-6 are the etiological agents of about 90 % of genital warts (GWs). The intra-typic variability of HPV-11 and its association with infection persistence and GW development remains undetermined. Here, HPV infection in men (HIM) participants who had an HPV-11 genital swab and/or GW, preceded or not by a normal skin genital swab were analysed. Genomic variants were characterized by PCR-sequencing and classified within lineages (A, B) and sublineages (A1, A2, A3, A4). HPV-11 A2 variants were the most frequently detected in the genital swab samples from controls and in both genital swabs and GW samples from cases. The same HPV-11 variant was detected in the GW sample and its preceding genital swab. There was a lack of association between any particular HPV-11 variant and the increased risk for GW development.
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