Revisiting the genotyping scheme for varicella-zoster viruses based on whole-genome comparisons | Zendy

Nancy J. Jensen | Zendy; Pierre Rivailler | Zendy; Hung Fu Tseng | Zendy; Mark L. Quinlivan | Zendy; Kay Radford | Zendy; Jennifer Folster | Zendy; Rafael Harpaz | Zendy; Philip LaRussa | Zendy; Steven J. Jacobsen | Zendy; D. Scott Schmid | Zendy

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Revisiting the genotyping scheme for varicella-zoster viruses based on whole-genome comparisons

Author(s) -

Nancy J. Jensen,

Pierre Rivailler,

Hung Fu Tseng,

Mark L. Quinlivan,

Kay Radford,

Jennifer Folster,

Rafael Harpaz,

Philip LaRussa,

Steven J. Jacobsen,

D. Scott Schmid

Publication year - 2017

Publication title -

journal of general virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.55

H-Index - 167

eISSN - 1465-2099

pISSN - 0022-1317

DOI - 10.1099/jgv.0.000772

Subject(s) - clade , genotyping , biology , virology , varicella zoster virus , genome , phylogenetic tree , genetics , virus , genotype , gene

We report whole-genome sequences (WGSs) for four varicella-zoster virus (VZV) samples from a shingles study conducted by Kaiser Permanente of Southern California. Comparative genomics and phylogenetic analysis of all published VZV WGSs revealed that strain KY037798 is in clade IX, which shall henceforth be designated clade 9. Previously published single nucleotide polymorphisms (SNP)-based genotyping schemes fail to discriminate between clades 6 and VIII and employ positions that are not clade-specific. We provide an updated list of clade-specific positions that supersedes the list determined at the 2008 VZV nomenclature meeting. Finally, we propose a new targeted genotyping scheme that will discriminate the circulating VZV clades with at least a twofold redundancy. Genotyping strategies using a limited set of targeted SNPs will continue to provide an efficient 'first pass' method for VZV strain surveillance as vaccination programmes for varicella and zoster influence the dynamics of VZV transmission.

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