Open AccessNaturally occurring recombination in ferret coronaviruses revealed by complete genome characterization
Author(s) -
Mart M. Lamers,
Saskia L. Smits,
Gadissa Bedada Hundie,
Lisette B. Provacia,
Marion Koopmans,
Albert D. M. E. Osterhaus,
Bart L. Haagmans,
V. Stalin Raj
Publication year - 2016
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/jgv.0.000520
Subject(s) - biology , genome , coronavirus , mink , phylogenetic tree , virology , clade , genetics , whole genome sequencing , phylogenetics , homology (biology) , gene , covid-19 , infectious disease (medical specialty) , medicine , ecology , disease , pathology
Ferret coronaviruses (FRCoVs) exist as an enteric and a systemic pathotype, of which the latter is highly lethal to ferrets. To our knowledge, this study provides the first full genome sequence of a FRCoV, tentatively called FRCoV-NL-2010, which was detected in 2010 in ferrets in The Netherlands. Phylogenetic analysis showed that FRCoV-NL-2010 is most closely related to mink CoV, forming a separate clade of mustelid alphacoronavirus that split off early from other alphacoronaviruses. Based on sequence homology of the complete genome, we propose that these mustelid coronaviruses may be assigned to a new species. Comparison of FRCoV-NL-2010 with the partially sequenced ferret systemic coronavirus MSU-1 and ferret enteric coronavirus MSU-2 revealed that recombination in the spike, 3c and envelope genes occurred between different FRCoVs.
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