A newly discovered flavivirus in the yellow fever virus group displays restricted replication in vertebrates | Zendy

Agathe M. G. Colmant | Zendy; Helle BielefeldtOhmann | Zendy; Jody HobsonPeters | Zendy; Willy W. Suen | Zendy; Caitlin A. O’Brien | Zendy; Andrew F. van den Hurk | Zendy; Roy A. Hall | Zendy

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A newly discovered flavivirus in the yellow fever virus group displays restricted replication in vertebrates

Author(s) -

Agathe M. G. Colmant,

Helle BielefeldtOhmann,

Jody HobsonPeters,

Willy W. Suen,

Caitlin A. O’Brien,

Andrew F. van den Hurk,

Roy A. Hall

Publication year - 2016

Publication title -

journal of general virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.55

H-Index - 167

eISSN - 1465-2099

pISSN - 0022-1317

DOI - 10.1099/jgv.0.000430

Subject(s) - biology , flavivirus , virology , flaviviridae , virus , genetics , phylogenetic tree , zika virus , hepatitis c virus , gene

A novel flavivirus, provisionally named Bamaga virus (BgV), was isolated from Culex annulirostris mosquitoes collected from northern Australia. Phylogenetic analysis of the complete nucleotide sequence of the BgV genome revealed it clustered with the yellow fever virus (YFV) group, and was most closely related to Edge Hill virus (EHV), another Australian flavivirus, with 61.9 % nucleotide and 63.7 % amino acid sequence identity. Antigenic analysis of the envelope and pre-membrane proteins of BgV further revealed epitopes common to EHV, dengue and other mosquito-borne flaviviruses. However, in contrast to these viruses, BgV displayed restricted growth in a range of vertebrate cell lines with no or relatively slow replication in inoculated cultures. There was also restricted BgV replication in virus-challenged mice. Our results indicate that BgV is an evolutionary divergent member of the YFV group of flaviviruses, and represents a novel system to study mechanisms of virus host-restriction and transmission.

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