Open AccessThe route of entry of leptospires into the kidney tubule (Plates X and XI)
Author(s) -
R.B. Marshall
Publication year - 1976
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-9-2-149
Subject(s) - kidney , leptospira interrogans , leptospira , serotype , pathology , interstitial space , tubule , biology , renal tubule , leptospirosis , anatomy , chemistry , microbiology and biotechnology , medicine , endocrinology
To study the migration of Leptospira interrogans serotype pomona through the kidney, conventionally-reared mice aged 2 or 3 weeks were infected intraperitoneally with this organism. Within the first 4 days, the organisms migrated from the capillary lumina to the interstitial tissue and provoked an interstitial oedema. By the 10th day they were seen between the epithelial cells of the proximal convoluted tubules and by the 14th day many were located within tubular lumina. There was no evidence of viable leptospires within the cells of the proximal tubules, though occasionally structures resembling leptospiral fragments inside lysosomes were observed. At no stage during the study were glomerular lesions seen.