Open AccessDIFFERENTIAL ABILITY OF COLONIAL TYPES OF NEISSERIA GONORRHOEAE TO PRODUCE INFECTION AND AN INFLAMMATORY RESPONSE IN SUBCUTANEOUS PERFORATED PLASTIC CHAMBERS IN GUINEA-PIGS AND RABBITS
Author(s) -
D. R. Veale,
H. Smith,
Kristina Witt,
R.B. Marshall
Publication year - 1975
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-8-2-325
Subject(s) - infectivity , neisseria gonorrhoeae , guinea pig , microbiology and biotechnology , biology , pathogenicity , transudate , immunology , virology , medicine , virus , pleural fluid , pleural effusion , endocrinology
Perforated plastic chambers implanted subcutaneously in guinea-pigs and rabbits became encapsulated and filled with sterile transudate. When these chambers in guinea-pigs were inoculated with various strans of Neisseria gonorrhoeae, persistent infections were achieved without the use of anti-inflammation agents and in the presence of a substantial predominantly polymorphonuclear inflammatory response. Two strains with small colonies similar to types 1 and 2, and one strain with large colonies similar to type 4 of Kellogg et al. (1963 and 1968), showed differences in infectivity comparable with those that might be expected in man, and passage through guinea-pig chambers increased this infectivity. Rabbit chambers could not be infected without the use of an anti-inflammation drug (betamethasone), and differences in infectivity between strains were not as clear cut. The growth of N. gonorrhoeae in chambers in the guinea-pig provides a convenient model system for studying some aspects of the pathogenicity of this organism.