An Outbreak of Epidemic Keratoconjunctivitis Caused by Adenovirus Type 37 | Zendy

Sally Curtis | Zendy; Gavin W. G. Wilkinson | Zendy; D. Westmoreland | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

An Outbreak of Epidemic Keratoconjunctivitis Caused by Adenovirus Type 37

Author(s) -

Sally Curtis,

Gavin W. G. Wilkinson,

D. Westmoreland

Publication year - 1998

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/00222615-47-1-91

Subject(s) - outbreak , genotyping , typing , serotype , virology , keratoconjunctivitis , restriction enzyme , mastadenovirus , medicine , neutralization , microbiology and biotechnology , biology , adenoviridae , genotype , virus , dna , recombinant dna , genetics , gene

An outbreak of acute keratoconjunctivitis in an ophthalmology department affected 15 patients and seven members of staff and necessitated temporary closure of the unit. Adenovirus (Ad) was isolated from eye swabs taken during the outbreak, but typing of the isolates by virus neutralisation assay proved unsatisfactory, wrongly assigning the isolate to serotype 10. A robust and rapid method for preparing microgram amounts of Ad DNA from infected cells was devised and used as the basis of a non-radioactive method for routine genotyping of adenovirus clinical isolates. All isolates associated with the outbreak, and one from a patient presenting at a nearby hospital during the outbreak, were found to have restriction endonuclease digestion patterns characteristic of Ad 37.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research