Open AccessGrowth hormone modulates IL- and IFN- release by murine splenocytes activated by LPS or porins of Salmonella Typhimurium
Author(s) -
Linda Sommese,
Giovanna Donnarumma,
G. Cipollaro De L'ero,
Antonella Marcatili,
Mariateresa Vitiello,
Massimiliano Galdiero
Publication year - 1996
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-45-1-40
Subject(s) - splenocyte , lipopolysaccharide , salmonella enterica , salmonella , microbiology and biotechnology , polymyxin , porin , cytokine , chemistry , biology , bacterial outer membrane , bacteria , endocrinology , biochemistry , immunology , in vitro , escherichia coli , antibiotics , gene , genetics
The effect of growth hormone (GH) on the release of IL-1alpha and IFN-gamma from murine splenocytes was investigated. Their release from splenocytes activated by Salmonella enterica serovar Typhimurium lipopolysaccharide (LPS) 0.5 microg/ml was increased by c. 65% in the presence of GH 100 pg/ml. With splenocytes activated by S. Typhimurium porins 5 microg/ml, GH increased the production of both IL-1alpha and IFN-gamma by c. 56%. Polymyxin treatment abolished the cytokine-releasing activity of LPS but had no effect on the activity of the porin preparation.