Open AccessInduction of IL-1 , IL-6, TNF- , GM-CSF and G-CSF in human macrophages by smooth transparent and smooth opaque colonial variants of Mycobacterium avium
Author(s) -
Lanfranco Fattorini,
Xuemin Yan,
B. Li,
C. Santoro,
Flora Ippoliti,
Graziella Orefici
Publication year - 1994
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-40-2-129
Subject(s) - microbiology and biotechnology , immune system , extracellular , macrophage , biology , bacteria , mycobacterium , tumor necrosis factor alpha , cytokine , strain (injury) , immunology , in vitro , genetics , anatomy
Both smooth transparent (SmT) and smooth domed-opaque (SmD) colonial variants were obtained from a strain of Mycobacterium avium isolated from a patient with AIDS. The two variants showed similar biochemical characteristics but SmT bacteria proliferated better than SmD bacteria inside human macrophages and were much less capable than the SmD variant of inducing the release of IL-1 beta, IL-6, TNF-alpha, GM-CSF and G-CSF, after incubation for either 3 or 6 days. As cytokines are important extracellular signals for immune cells, the lack of induction observed in SmT-infected macrophages may be one of the pathogenic mechanisms of M. avium.