Open AccessKilling of pathogens associated with chronic granulomatous disease by the non-oxidative microbicidal mechanisms of human neutrophils
Author(s) -
Edward Odell,
AW Segal
Publication year - 1991
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-34-3-129
Subject(s) - chronic granulomatous disease , microbiology and biotechnology , serratia marcescens , aspergillus fumigatus , candida albicans , biology , staphylococcus aureus , virulence , pathogen , immunology , escherichia coli , bacteria , biochemistry , genetics , gene
The susceptibility of opportunist pathogens associated with chronic granulomatous disease (CGD) to the non-oxidative killing mechanisms of neutrophils has been assessed by incubation in human neutrophil primary granule lysate. The dose and pH-dependency of killing of Aspergillus fumigatus, Candida albicans, Escherichia coli, Nocardia asteroides, Serratia marcescens and Staphylococcus aureus differed markedly and may partly explain their virulence in CGD, in which oxygen-dependent killing mechanisms are defective. At the acid pH in CGD neutrophil phagosomes S. aureus, Ser. marcescens, N. asteroides and A. fumigatus spores were highly resistant but C. albicans, a less frequent pathogen in patients with CGD, was much more susceptible.