Open AccessThe bactericidal activity of DR-3355, an optically active isomer of ofloxacin
Author(s) -
C. S. Lewin,
S. G. B. Amyes
Publication year - 1989
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-30-3-227
Subject(s) - ofloxacin , bacteria , staphylococcus epidermidis , escherichia coli , microbiology and biotechnology , enterobacteriaceae , staphylococcus aureus , antibacterial agent , chemistry , biology , biochemistry , antibiotics , genetics , ciprofloxacin , gene
The bactericidal activity of compound DR-3355, an optically active isomer of ofloxacin, was measured against Escherichia coli, Staphylococcus aureus and S. epidermidis, in nutrient broth and in phosphate-buffered saline. DR-3355 was found to be approximately twice as active as ofloxacin in terms of the concentration at which maximum bacterial kill was achieved. Hence it appears that DR-3355 is twice as active as ofloxacin not only in terms of its ability to inhibit bacterial multiplication but also in its ability to kill bacteria. DR-3355 was found to be active against non-dividing bacteria and did not require either active RNA or protein biosynthesis in order to kill bacteria.