Open AccessOpsonophagocytosis of Campylobacter pylori
Author(s) -
Subhasish Das,
Q. N. Karim,
C. S. F. Easmon
Publication year - 1988
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-27-2-125
Subject(s) - campylobacter , opsonin , antibody , gastritis , alternative complement pathway , immunology , helicobacter pylori , medicine , complement system , microbiology and biotechnology , complement (music) , bacteria , biology , gastroenterology , genetics , biochemistry , phenotype , complementation , gene
The opsonic activity of human serum from various sources against Campylobacter pylori was compared. All sera, whether from control subjects with no symptoms of gastritis or peptic ulceration, or from symptomatic patients from whom C. pylori had or had not been isolated, opsonised C. pylori equally well. Opsonisation depended on the alternative pathway of complement activation but not on antibody. These findings suggest that antibody plays no role in protection against C. pylori and that the presence of antibody in patients' sera is mainly of diagnostic value.