Open AccessInteraction of Campylobacter pyloridis with human immune defence mechanisms
Author(s) -
H. Pruul,
P. C. Lee,
C. S. Goodwin,
Peter J. McDonald
Publication year - 1987
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-23-3-233
Subject(s) - opsonin , campylobacter , immune system , microbiology and biotechnology , complement system , in vitro , alternative complement pathway , complement (music) , phagocytosis , classical complement pathway , immunology , biology , immunity , bacteria , biochemistry , genetics , complementation , gene , phenotype
The in-vitro susceptibility to host immune defence mechanisms of Campylobacter pyloridis was investigated. C. pyloridis was sensitive to antibody-dependent complement-mediated bactericidal activity of serum. The bacteria were phagocytosed and efficiently killed by polymorphonuclear neutrophils in the presence of serum opsonins. Serum opsonin depletion studies indicated that an intact classical complement pathway was required for optimal phagocytic killing.