Open AccessSERUM FACTORS FOR OPSONISATION OF NON-TYPABLE HAEMOPHILUS INFLUENZAE
Author(s) -
A. M. L. Lever,
Jordan M. Gross,
Alison Webster
Publication year - 1985
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-20-1-33
Subject(s) - opsonin , phagocytosis , haemophilus influenzae , microbiology and biotechnology , antibody opsonization , immunology , antibody , haemophilus , biology , bacteria , antibiotics , genetics
Neutrophil chemiluminescence was used to assess the opsonins required for phagocytosis of non-typable Haemophilus influenzae isolated from sputum samples of patients with hypogammaglobulinaemia. Immunoglobulin was the major opsonin, whereas complement was relatively unimportant. Evidence was found for a heat-labile opsonin other than complement that enhanced phagocytosis of these organisms. Tuftsin was shown to aid phagocytosis of H. influenzae without triggering chemiluminesence.