Open AccessCROSSREACTIVITY AS A FACTOR IN THE IMMUNE RESPONSE TO SALMONELLA TYPHIMURIUM IN CBA AND BALB/C MICE
Author(s) -
Paul H. Wooley,
Alan Ebringer
Publication year - 1980
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-13-1-11
Subject(s) - antibody , immune system , antiserum , antigen , salmonella , balb/c , agglutination (biology) , spleen , biology , microbiology and biotechnology , immunology , bacteria , genetics
The immune response to Salmonella typhimurium was investigated in CBA and BALB/C mice, by an arithmetic Widal agglutination assay. High antibody titres were obtained in CBA and low titres in BALB/C mice after secondary immunisation. A rabbit antiserum raised against S. typhimurium was tested for agglutinating activity after absorption with spleen- and lymph-node cells obtained from unimmunised CBA or BALB/C mice. BALB/C cells consistently removed more anti-S. typhimurium antibodies than did CBA cells, whilst the quantities of Fc receptor-bearing cells were found to be similar in both strains when measured by the erythrocyte-antibody rosette technique. It is suggested BALB/C mice give a low antibody response because their cell-surface antigens crossreact to a greater degree with S. typhimurium than do CBA cell-surface antigens.