Open AccessSex Pili as Immunogens
Author(s) -
Smith Hw,
Huggins Mb
Publication year - 1975
Publication title -
journal of general microbiology/journal of general microbiology
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2059-9323
pISSN - 0022-1287
DOI - 10.1099/00221287-89-1-133
Subject(s) - salmonella , strain (injury) , pilus , microbiology and biotechnology , escherichia coli , vaccination , biology , enterobacteriaceae , immunity , virology , bacteria , immune system , immunology , genetics , gene , anatomy
Groups of chickens were vaccinated intravenously with live cultures of Escherichia coli K12 possessing transfer factors F, I, A2 or no transfer factor (Tra-minus) and their immunity challenged by injecting them intravenously with an F-plus strain of Salmonella heidelberg or an F-plus or I-plus strain of Salmonella typhimurium. Compared with the Tra-minus strain, vaccination with the F-plus, but not the I-plus or A2-plus, K12 strain significantly reduced the mortality rate caused by the F-plus salmonella strains; vaccination with the I-plus or A2-plus, but not the F-plus, K12 strain significantly reduced the mortality rate caused by the I-plus salmonella strain.