Effects of Staphylococcal -Toxin on the Structure of Erythrocyte Membranes: a Biochemical and Freeze-etching study | Zendy

John H. Freer | Zendy; J. P. Arbuthnott | Zendy; B. Billcliffe | Zendy

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Effects of Staphylococcal -Toxin on the Structure of Erythrocyte Membranes: a Biochemical and Freeze-etching study

Author(s) -

John H. Freer,

J. P. Arbuthnott,

B. Billcliffe

Publication year - 1973

Publication title -

journal of general microbiology

Language(s) - English

Resource type - Journals

eISSN - 2059-9323

pISSN - 0022-1287

DOI - 10.1099/00221287-75-2-321

Subject(s) - toxin , membrane , chemistry , erythrocyte membrane , biophysics , microbiology and biotechnology , electron microscope , biochemistry , biology , physics , optics

SUMMARY: A correlated electron microscopy and biochemical study of the effects of staphylococcal α-toxin on rabbit erythrocyte membrane structure has been carried out. Using several criteria, no evidence was obtained for the involvement of a proteolytic mechanism in the mode of action of this toxin.After toxin treatment, ghosts examined by freeze-etching showed changes in micromorphology consistent with a hydrophobic interaction between toxin and membrane.

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