Monoclonal Antibodies against Human Paramyxovirus Type 3 and against SV5 Virus: Preparation and Preliminary Characterization
Author(s) -
K. K. A. Goswami,
W. C. Russell
Publication year - 1983
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-64-8-1663
Subject(s) - biology , virology , monoclonal antibody , virus , antibody , immunology
Monoclonal antibodies against the major glycoprotein (HN) and the nucleoprotein (NP) of paramyxovirus SV5 and human paramyxovirus (PF) type 3 have been obtained. Two different epitopes have been detected on the SV5 HN polypeptide, one being specific to SV5 and the other also cross-reacting with PF-2 HN polypeptide. Monoclonal antibody against SV5 NP polypeptide also reacted with PF-2 NP polypeptide. Similar epitopes showing both specific and group cross-reactions were detected with PF-3 HN and NP monoclonal antibodies against PF-3 and Sendai viruses. No cross-reactions were detected between these two groups of paramyxoviruses.
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