Open AccessThe bactericidal activity of gemifloxacin (SB-265805)
Author(s) -
Ian Morrissey,
Stephen Nowland Clark,
I. Mathias
Publication year - 2000
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/0022-1317-49-9-841
Subject(s) - gemifloxacin , lomefloxacin , trovafloxacin , microbiology and biotechnology , ciprofloxacin , streptococcus pneumoniae , levofloxacin , enoxacin , ofloxacin , moxifloxacin , staphylococcus aureus , antibacterial agent , chemistry , klebsiella pneumoniae , escherichia coli , bacteria , biology , antibiotics , biochemistry , genetics , gene
The bactericidal activity and mechanisms of action of the new fluoroquinolone gemifloxacin were investigated against the laboratory strains Escherichia coli KL16, Staphylococcus aureus E3T and Streptococcus pneumoniae C3LN4. Gemifloxacin was found to be highly bactericidal against these bacteria, producing a biphasic dose-response curve typical of the fluoroquinolones. This novel fluoroquinolone was more bactericidal than all other fluoroquinolones so far tested (ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, levofloxacin, clinafloxacin, trovafloxacin, DV-7751 and sitafloxacin) against S. aureus and was more bactericidal than most other fluoroquinolones against E. coli or Str. pneumoniae. These data show gemifloxacin to be an improved member of the fluoroquinolone class of antibacterial agents.