Interferon Production by Human-Mouse Hybrid Cells: Dominant Mouse Control of Superinduction and Priming | Zendy

H E Graves | Zendy; Anthony Meager | Zendy

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Interferon Production by Human-Mouse Hybrid Cells: Dominant Mouse Control of Superinduction and Priming

Author(s) -

H E Graves,

Anthony Meager

Publication year - 1980

Publication title -

journal of general virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.55

H-Index - 167

eISSN - 1465-2099

pISSN - 0022-1317

DOI - 10.1099/0022-1317-47-2-489

Subject(s) - biology , priming (agriculture) , interferon , virology , virus , cell culture , microbiology and biotechnology , genetics , botany , germination

We have examined the production of interferon by a number of human-mouse hybrid clones in response to polyriboinosinic acid:polyribocytidylic acid copolymer [poly(rI).poly(rC)] all of which produced both human and mouse interferons when stimulated with a virus. Their capacity to be superinduced and primed for interferon production in response to poly(rI).poly(rC) was compared to that of the parental human and mouse cells. It was found that the hybrids responded in a way similar to their mouse cell parents, indicating dominant mouse control of both the priming and superinduction phenomena.

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