Evidence for a New Antigen within the Adenovirus Capsid | Zendy

W. C. Russell | Zendy; B. E. Knight | Zendy

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Evidence for a New Antigen within the Adenovirus Capsid

Author(s) -

W. C. Russell,

B. E. Knight

Publication year - 1967

Publication title -

journal of general virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.55

H-Index - 167

eISSN - 1465-2099

pISSN - 0022-1317

DOI - 10.1099/0022-1317-1-4-523

Subject(s) - antiserum , capsid , complement fixation test , virology , antigen , biology , agglutination (biology) , capsomere , serology , virus , latex fixation test , microbiology and biotechnology , antibody , immunology

SUMMARY Complement-fixation and radioactive-agglutination tests were performed on purified preparations of adenovirus type 5 using specific antisera against capsid antigens and an antiserum which can detect an antigen (the P antigen) in infected cells which has many of the properties of the T antigen associated with infection by the oncogenic adenoviruscs. A serological reaction was detected between preparations containing intact virions and antihexon serum but not with antisera against fibres, penton bases and the P antigen. However, virus preparations which had been 'aged' at 4 ° , and in which electron microscopic examination revealed the presence of many broken capsids, did react in complement fixation and radioactive agglutination with all the antisera. It was concluded that within the adenovirus capsid there is a hitherto undescribed protein related to the P antigen.

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