Macropinocytosis and autophagy crosstalk in nutrient scavenging | Zendy

Oliver Florey | Zendy; Michael Overholtzer | Zendy

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Macropinocytosis and autophagy crosstalk in nutrient scavenging

Author(s) -

Oliver Florey,

Michael Overholtzer

Publication year - 2018

Publication title -

philosophical transactions of the royal society b biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.753

H-Index - 272

eISSN - 1471-2970

pISSN - 0962-8436

DOI - 10.1098/rstb.2018.0154

Subject(s) - pinocytosis , autophagy , crosstalk , nutrient , nutrient deficiency , microbiology and biotechnology , biology , chemistry , ecology , cell , biochemistry , endocytosis , apoptosis , engineering , electronic engineering

Adaptive strategies used by cells to scavenge and recycle essential nutrients are important for survival in nutrient-depleted environments such as cancer tissues. Autophagy and macropinocytosis are two major mechanisms that promote nutrient recycling and scavenging, which share considerable, yet poorly understood, cross-regulation. Here we review recent findings that connect these starvation response mechanisms and discuss the implications of their crosstalk. This article is part of the Theo Murphy meeting issue ‘Macropinocytosis’.

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